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What we have published

Primary research (selected)

Jessica Wagner*, Karoline Degenhardt*, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker & Jonas J. Neher (2022) Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. Nature, online ahead of print.

Karoline Degenhardt*, Jessica Wagner*, Angelos Skodras, Michael Candlish, Anna Julia Koppelmann, Katleen Wild, Rusheka Maxwell, Carola Rotermund, Felix von Zweydorf, Christian Johannes Gloeckner, Hannah A Davies, Jillian Madine, Domenico Del Turco, Regina Feederle, Tammaryn Lashley, Thomas Deller, Philipp Kahle, Jasmin K Hefendehl, Mathias Jucker, Jonas J Neher (2020) Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. Proceedings of the National Academy of Sciences of the United States of America 117:  38.  23925-23931 09. 

Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F Lichtenthaler, Stephan A Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A Grathwohl, Jonas J Neher, David M Holtzman, Melanie Meyer-Luehmann, Christian Haass (2019)  Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience 22:  2.  191-204 02. 

Ann-Christin Wendeln*, Karoline Degenhardt*, Lalit Kaurani, Michael Gertig, Thomas Ulas, Gaurav Jain, Jessica Wagner, Lisa M Häsler, Katleen Wild, Angelos Skodras, Thomas Blank, Ori Staszewski, Moumita Datta, Tonatiuh Pena Centeno, Vincenzo Capece, Md Rezaul Islam, Cemil Kerimoglu, Matthias Staufenbiel, Joachim L Schultze, Marc Beyer, Marco Prinz, Mathias Jucker, André Fischer, Jonas J Neher (2018)  Innate immune memory in the brain shapes neurological disease hallmarks. Nature  556:  7701.  332-338 04. 

Petra Füger, Jasmin K Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S Sisodia, Angelos Skodras, Mathias Jucker (2017)  Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. 
Nature Neuroscience 20:  10.  1371-1376 Oct. 

Julius V Emmrich, Jonas J Neher, Philipp Boehm-Sturm, Matthias Endres, Ulrich Dirnagl, Christoph Harms (2017)  Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo).  F1000Research 6:  10. 

Nicholas H Varvel, Jonas J Neher, Andrea Bosch, Wenyi Wang, Richard M Ransohoff, Richard J Miller, Raymond Dingledine (2016)  Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proceedings of the National Academy of Sciences of the United States of America 113:  38.  E5665-E5674 09. 

Nicholas H Varvel, Stefan A Grathwohl, Karoline Degenhardt, Claudia Resch, Andrea Bosch, Mathias Jucker, Jonas J Neher  (2015)  Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease. The Journal of Experimental Medicine  212:  11.  1803-1809 Oct. 

Julius V Emmrich, Sohail Ejaz, Jonas J Neher, David J Williamson, Jean-Claude Baron (2015)  Regional distribution of selective neuronal loss and microglial activation across the MCA territory after transient focal ischemia: quantitative versus semiquantitative systematic immunohistochemical assessment.  Journal of Cerebral Blood Flow and Metabolism 35:  1.  20-27 Jan. 

Jack Brelstaff, Bernardino Ossola, Jonas J Neher, Therése Klingstedt, K Peter R Nilsson, Michel Goedert, Maria Grazia Spillantini, Aviva M Tolkovsky (2015)  The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Frontiers in Neuroscience 9: 05.

Jasmin K Hefendehl, Jonas J Neher, Rafael B Sühs, Shinichi Kohsaka, Angelos Skodras, Mathias Jucker (2014) Homeostatic and injury-induced microglia behavior in the aging brain.  Aging Cell 13:  1.  60-69 Feb. 

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Reviews and Commentaries

Jillian Madine, Hannah A. Davies HA, Raymond Q. Migrino, Sanni E. Ruotsalainen, Jessica Wagner, Jonas J. Neher (2023) Medin amyloid may drive arterial aging and disease in the periphery and brain. Nature Aging 3(9): 1039-1041.

Jonas J Neher (2022)  InFlamiN’ the brain in Alzheimer’s disease. Immunity 55:  5.  821-823.

Rosa Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay,…, Jonas J. Neher, … (total of 90+ authors) (2022)  Microglia states and nomenclature: A field at its crossroads. Neuron 110:  21.  3458-3483.

Jonas J Neher (2021)  Reversal of immune-cell shutdown protects the ageing brain. Nature 590:  7844.  44-45 02.

Michael R Nichols, Marie-Kim St-Pierre, Ann-Christin Wendeln, Nyasha J Makoni, Lisa K Gouwens, Evan C Garrad, Mona Sohrabi, Jonas J Neher, Marie-Eve Tremblay, Colin K Combs (2019)   Inflammatory mechanisms in neurodegeneration. 
Journal of Neurochemistry 149:  5.  562-581 06. 

Jonas J Neher, Colm Cunningham (2019)  Priming Microglia for Innate Immune Memory in the Brain. 
Trends in Immunology 40:  4.  358-374 04. 

Guy C Brown, Jonas J Neher (2014)  Microglial phagocytosis of live neurons. Nature Reviews Neuroscience 15:  4.  209-216 Apr. 

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